The Creative Artificial Intelligence Networking Entity, colloquially abbreviated Caine, is the main antagonist of Glitch Productions' indie animated web series The Amazing Digital Circus who is voiced by Alex Rochon.

Jax is the deuteragonist of Glitch Productions' indie animated web series The Amazing Digital Circus, voiced by Michael Kovach. He is a lanky lilac rabbit with a monotone voice and antagonistic tendencies who is trapped in the Digital Circus along with five other victims.

Jazzy is a vampire Shih Tzu demon. She used to be human, but she transformed into a giant Shih Tzu

Yuri Briar (ユーリ・ブライア, Yūri Buraia?) is one of the recurring characters and the secondary antagonist of the SPY x FAMILY series. He is Yor Forger's younger brother and a twenty-year-old man who works in Ostania's State Security Service. Yuri keeps his job at the SSS a secret from his sister and instead pretends to be a normal civil servant and diplomat at the foreign ministry.

Bindle Boogie is a rejected toy created by Playtime Co. as part of the Wrongside Outimals toy line.

Doodle Bones is a rejected toy created by Playtime Co. as part of the Wrongside Outimals toy line.

Doctor Ivo Robotnik (ドクター・イヴォ・ロボトニック, Dokutā Ivo Robotonikku?), better known by the alias Doctor Eggman (ドクター・エッグマン), Dokutā Egguman?), is the main antagonist of the Sonic the Hedgehog series. A brilliant scientist with an IQ of 300, Dr. Eggman is driven by a desire to conquer the world and establish his own empire, the Eggman Empire. Central to his vision is Eggmanland, an amusement park he seeks to build as the backbone of his regime. His ambitions are fueled by his love of machines and extreme egomania.

Candy Cat is a toy created by Playtime Co. who makes her debut in Chapter 1: A Tight Squeeze of Poppy Playtime.

PJ Pug-a-Pillar is a toy produced by Playtime Co. as part of the Swap-imals toy line. He debuted in Chapter 2: Fly in a Web as the main antagonist of the Statues minigame.

Icky Licky is a toy produced by Playtime Co. as part of the Nightmare Critters toy line. He appears in Chapter 4: Safe Haven as a minor antagonist in the form of a small hostile plush toys.

Lavender dreams is the princess of “Sparkle land” and is also CatNaps adopted sister.

Rabie Babyis a toy produced by Playtime Co. as part of the Nightmare Critters toy line. She appears in Chapter 4: Safe Haven as a minor antagonist in the form of small hostile plush toys.

Poe is a toy produced by Playtime Co. as part of the Nightmare Critters toy line. They appear in Chapter 4: Safe Haven as a minor antagonist in the form of small hostile plush toys.

Samual (other known as Papa Wofl) is the father of Sinder, and has a wife named Samantha

Samantha (also known as mama wolf) is a hellhound woman and the mother of Sinder

King Spencer is the ice king, he has a wife named “Queen Eira” and they both had a daughter named “Princess Icey”

Kissy Missy was one of the two main deuteragonists of Poppy Playtime, alongside the character of the same name. She was a toy produced by Playtime Co. and created in 1985, one year after Huggy Wuggy's release.

Glowby is an item that is found within Chapter 5: Broken Things of Poppy Playtime. It is a Playtime Interactive Media product that serves as a companion.

Giblet is a toy produced by Playtime Co. that appears as the deuteragonist in Chapter 5: Broken Things.